Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids.
Mario CioceMaria Rita FumagalliSara DonzelliFrauke GoemanValeria CanuDaniela RutiglianoGiulia OrlandiAndrea SacconiClaudio PulitoAlina Catalina PalcauMaurizio FanciulliAldo MorroneMaria Grazia DiodoroMarco CaricatoAnna CrescenziMartina VerriVito Michele FazioStefano ZapperiMassimo LevreroSabrina StranoGian Luca GraziCaterina La PortaGiovanni BlandinoPublished in: Journal of experimental & clinical cancer research : CR (2023)
Pentoxifylline synergizes with 5-Fluorouracil (5-FU) in attenuating organoid formation. It does so by interfering with an IL-6-STAT3 axis leading to the emergence of chemoresistant ALDHhigh cell subpopulations in 5-FU treated PDOs. A larger cohort of CRC-PDOs will be required to validate and expand on the findings of this proof-of-concept study.