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Native glycan fragments detected by MALDI mass spectrometry imaging are independent prognostic factors in pancreatic ductal adenocarcinoma.

Na SunMarija Trajkovic-ArsicFengxia LiYin WuCorinna MünchThomas KunzkeAnnette FeuchtingerKatja SteigerAnna Melissa SchlitterWilko WeichertIrene EspositoJens Thomas SivekeAxel Walch
Published in: EJNMMI research (2021)
Our method allows in situ detection of naturally occurring glycans in FFPE samples of human PDAC tissue and highlights the differences among glycans found in stromal and cancer cell compartment offering a basis for further exploration on the role of specific glycans in cancer-stroma communication.
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