Native glycan fragments detected by MALDI mass spectrometry imaging are independent prognostic factors in pancreatic ductal adenocarcinoma.
Na SunMarija Trajkovic-ArsicFengxia LiYin WuCorinna MünchThomas KunzkeAnnette FeuchtingerKatja SteigerAnna Melissa SchlitterWilko WeichertIrene EspositoJens Thomas SivekeAxel WalchPublished in: EJNMMI research (2021)
Our method allows in situ detection of naturally occurring glycans in FFPE samples of human PDAC tissue and highlights the differences among glycans found in stromal and cancer cell compartment offering a basis for further exploration on the role of specific glycans in cancer-stroma communication.
Keyphrases
- prognostic factors
- cell surface
- mass spectrometry
- high resolution
- endothelial cells
- liquid chromatography
- papillary thyroid
- bone marrow
- capillary electrophoresis
- squamous cell
- high performance liquid chromatography
- induced pluripotent stem cells
- label free
- loop mediated isothermal amplification
- squamous cell carcinoma
- ms ms
- childhood cancer
- tandem mass spectrometry
- young adults
- photodynamic therapy