FcγRIIb Exacerbates LPS-Induced Neuroinflammation by Binding with the Bridging Protein DAP12 and Promoting the Activation of PI3K/AKT Signaling Pathway in Microglia.
YingWen HanLuyao WangXiaokun YeXue GongXiaoyi ShaoPublished in: Journal of inflammation research (2024)
Altogether, our experiments indicate that FcγRIIb interacts with DAP12 to promote microglia activation by activating the PI3K-AKT pathway while leading to neuronal apoptosis and exacerbating brain tissue injury, which may provide a new target for the treatment of inflammatory diseases in the central nervous system.
Keyphrases
- pi k akt
- lps induced
- signaling pathway
- inflammatory response
- cell cycle arrest
- lipopolysaccharide induced
- oxidative stress
- induced apoptosis
- binding protein
- epithelial mesenchymal transition
- cell proliferation
- cerebral ischemia
- neuropathic pain
- cell death
- endoplasmic reticulum stress
- white matter
- multiple sclerosis
- amino acid
- combination therapy
- spinal cord injury
- cognitive impairment
- smoking cessation
- functional connectivity
- brain injury