Novel retinopathy in related Gordon setters: a clinical, behavioral, electrophysiological, and genetic investigation.

Kathryn L GoodAndrás M KomáromyPhilip H KassRon Ofri

Published in: Veterinary ophthalmology (2015)

This report describes a novel retinopathy in related Gordon setters that has clinical signs and vision testing results consistent with achromatopsia but electroretinographic results suggestive of cone-rod dystrophy. The majority of Gordon setters in this study had low rod responses on electroretinography but it is unclear whether this was indicative of rod dysfunction or normal for the breed. Longer-term observation of affected individuals is warranted.

Keyphrases

oxidative stress
early onset
gene expression
copy number
gestational age