Oncogenic KRAS Induces Arginine Auxotrophy and Confers a Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell Lung Cancer.

Xiameng Gai Yingluo Liu Xiaojing Lan Luoyi Chen Tao Yuan Jun Xu Yize Li Ying Zheng Yiyang Yan Liya Yang Yixian Fu Shuai Tang Siyuwei Cao Xiaoyang Dai Hong Zhu Meiyu Geng Jian Ding Congying Pu Min Huang

Published in: Cancer research (2024)

ASS1 deficiency is induced by mutant KRAS in NSCLC to facilitate DNA synthesis and creates a dependency on SLC7A1, revealing dietary arginine restriction and SLC7A1 inhibition as potential therapeutic strategies.

Keyphrases

wild type
nitric oxide
small cell lung cancer
climate change
circulating tumor
single molecule
transcription factor
amino acid
human health
risk assessment
brain metastases