The role of opioids in cancer response to immunotherapy.

Andrea BotticelliAlessio CirilloGiulia PomatiBruna CerbelliSimone ScagnoliMichela RobertoAlain GelibterGiulia MammoneMaria Letizia CalandrellaEdoardo CerbelliFrancesca Romana Di PietroFederica De GalitiisGaetano LanzettaEnrico CortesiSilvia MeziPaolo Marchetti

Published in: Journal of translational medicine (2021)

A possible negative drug interaction able to impair the immune response to anti-PD-1/PD-L1 agents has been highlighted. Our findings suggest the need to further explore the impact of opioids on immune system modulation and their role in restoring the response to immunotherapy treatment, thereby improving patients' outcomes.

Keyphrases

end stage renal disease
chronic pain
ejection fraction
pain management
chronic kidney disease
newly diagnosed
papillary thyroid
prognostic factors
type diabetes
emergency department
young adults
patient reported outcomes
glycemic control
smoking cessation