Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy.

Aksel LaudonZhaoze WangAnqi ZouRicha SharmaJiayi JiConnor KimYingzhe QianQin YeHui ChenJoel M HendersonChao ZhangVijaya B KolachalamaWeining Lu

Published in: bioRxiv : the preprint server for biology (2024)

We leveraged U-Net architecture in an algorithm to measure the widths of glomerular basement membrane and podocyte foot processes.Deep learning-based automated measurement of glomerular filtration barrier morphology has promise in podocytopathy research and diagnosis.

Keyphrases

deep learning
diabetic nephropathy
high glucose
machine learning
endothelial cells
artificial intelligence
convolutional neural network
big data
high throughput
electron microscopy