Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity.

Samanta Romina ZanettiPaola Alejandra RomecinMeritxell VinyolesManel JuanJosé Luis FusterMireia CámosSergi QuerolMario DelgadoPablo Menendez

Published in: Journal for immunotherapy of cancer (2021)

Collectively, our data demonstrate that pediatric B-ALL and HD BM-MSC equally immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity.

Keyphrases

bone marrow
mesenchymal stem cells
nk cells
electronic health record
big data
machine learning
artificial intelligence