In vitro safety of ketotifen as a topical nasal rinse.
Vasiliki TriantafillouIvy W MainaNeil N PatelCharles C L TongPeter PapagiannopoulosMichael A KohanskiDavid W KennedyJames N PalmerNithin D AdappaNoam A CohenJohn V BossoPublished in: International forum of allergy & rhinology (2021)
Topical application of ketotifen to an in vitro model of sinonasal epithelium is safe, as evaluated by CBF and lactate dehydrogenase. Ketotifen is neither ciliotoxic nor ciliostimulatory, and no long-term cellular toxicity was observed. Ketotifen may have promise as a topical nasal rinse in the treatment of AERD.