SOCS6 promotes radiosensitivity and decreases cancer cell stemness in esophageal squamous cell carcinoma by regulating c-Kit ubiquitylation.

Xuanzi SunYuchen SunJing LiXu ZhaoXiaobo ShiTuotuo GongShupei PanZhongqiang ZhengXiaozhi Zhang

Published in: Cancer cell international (2021)

Our findings suggest that SOCS6 can promote the radiosensitivity of HPV+ ESCC and ESCC cells and reduce their stemness via ubiquitylation and degradation of c-Kit. Thus, SOCS6 is a potential target for overcoming radioresistance of ESCC.

Keyphrases

stem cells
epithelial mesenchymal transition
induced apoptosis
cancer stem cells
cell cycle arrest
high grade
signaling pathway
endoplasmic reticulum stress
risk assessment
cell death
dna damage response
climate change
human health
cell proliferation