Gold(I)-Initiated Cycloisomerization/Diels-Alder/Retro-Diels-Alder Cascade Strategy to Biaryls.
Shengfei JinYujie NiuChengjun LiuLifeng ZhuYangming LiShanshan CuiZhiling XiongMaosheng ChengBin LinYong-Xiang LiuPublished in: The Journal of organic chemistry (2017)
A unique approach to biaryls was developed on the basis of propargyl vinyl ethers and dienophiles substrates via a gold(I)-initiated cycloisomerization/Diels-Alder/retro-Diels-Alder cascade reaction. The scope and mechanism of the reaction were investigated on the basis of a series of synthetic substrates, control experiments, and DFT calculations.