Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer.
Naomi ElsterSinead ToomeyYue FanMattia CremonaClare MorganKarolina Weiner GorzelUna BhreathnachMalgorzata MilewskaMadeline MurphyStephen MaddenJarushka NaidooJoanna FayElaine KayAoife CarrSean KennedySimon FurneyJanusz MezynskiOscar BreathhnachPatrick MorrisLiam GroganArnold HillSusan KennedyJohn CrownWilliam GallagherBryan HennessyAlexander J EustacePublished in: Therapeutic advances in medical oncology (2018)
ERBB gene family mutations, which are present in 7% of our HER2+ breast cancer cohort, may have the potential to alter cellular behaviour and the efficacy of HER- and PI3K-inhibition.