Liver steatosis is highly prevalent and is associated with metabolic risk factors and liver fibrosis in adult patients with type 1 Gaucher disease.

Fabio NascimbeniSimonetta LugariElena CassinerioIrene MottaAlessia CavicchioliAnnalisa Dalla SaldaSerena BursiSalvatore DonatielloVincenzo SpinaMaria Domenica CappelliniPietro Andreone Francesca Carubbi

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

Significant steatosis is highly prevalent in adult type 1 GD patients and is strongly associated with a worse metabolic profile, featuring metabolic dysfunction-associated fatty liver disease (MAFLD). MAFLD may determine liver fibrosis progression in GD patients on stable ERT and may be a risk factor for long-term liver-related complications.

Keyphrases

liver fibrosis
end stage renal disease
risk factors
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
insulin resistance
metabolic syndrome
patient reported outcomes
young adults
replacement therapy