AMPKα inactivation destabilizes atherosclerotic plaque in streptozotocin-induced diabetic mice through AP-2α/miRNA-124 axis.
Wen-Jing LiangSheng-Nan ZhouMei-Rong ShanXue-Qin WangMiao ZhangYuan ChenYun ZhangShuang-Xi WangTao GuoPublished in: Journal of molecular medicine (Berlin, Germany) (2018)
Hyperglycemia reduced collagen synthesis, leading to the formation of unstable atherosclerotic plaque induced by collar placement around carotid in apolipoprotein E knockout mice. Hyperglycemia destabilizes atherosclerotic plaque in vivo through an AMPKα/AP-2α/miRNA-124/P4Hα1-dependent collagen synthesis. Metformin functions as a stabilizer of atherosclerotic plaque to reduce acute coronary accent.
Keyphrases
- coronary artery disease
- diabetic rats
- oxidative stress
- transcription factor
- skeletal muscle
- drug induced
- liver failure
- high fat diet
- type diabetes
- metabolic syndrome
- respiratory failure
- heart failure
- high glucose
- intensive care unit
- hepatitis b virus
- endothelial cells
- left ventricular
- aortic stenosis
- diabetic nephropathy
- aortic valve
- stress induced