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Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study.

Ranjit Mohan AnjanaViswanathan BaskarAnand Thakarakkattil Narayanan NairSaravanan JebaraniMoneeza Kalhan SiddiquiRajendra PradeepaRanjit UnnikrishnanColin PalmerEwan PearsonViswanathan Mohan
Published in: BMJ open diabetes research & care (2021)
Compared with previously reported clustering, we show two novel subgroups of type 2 diabetes in the Asian Indian population with important implications for prognosis and management. The coexistence of insulin deficiency and insulin resistance seems to be peculiar to the Asian Indian population and is associated with an increased risk of microvascular complications.
Keyphrases
  • type diabetes
  • insulin resistance
  • glycemic control
  • adipose tissue
  • cardiovascular disease
  • high fat diet
  • metabolic syndrome
  • risk factors
  • single cell
  • rna seq
  • replacement therapy