Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey.
Naoko MatsuiKeiko TanakaMitsuyo IshidaYohei YamamotoYuri MatsubaraReiko SaikaTakahiro IizukaKoshi NakamuraNagato KuriyamaMakoto MatsuiKokichi ArisawaYosikazu NakamuraRyuji KajiSatoshi KuwabaraYuishin Izuminull nullPublished in: Neurology(R) neuroimmunology & neuroinflammation (2023)
This study provides the current epidemiologic and clinical status of SPS in Japan. The symptom onset to the diagnosis of SPS was longer in patients with high-titer GAD65 antibodies than in those with low-titer GAD65 antibodies. The outcome of patients with SPS was generally favorable, but more aggressive immunotherapies are necessary for GAD65-positive patients with SPS.
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