Aging gene signature of IL-7 receptor alpha low effector memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer's disease.
Juan YoungHong-Jai ParkMinhyung KimJennefer Par-YoungHugh BartlettHye Sun KimSerhan UnluLais OsmaniMin Sun ShinRichard BucalaChristopher van DyckHeather G AlloreAdam MeccaSungyong YouInsoo KangPublished in: Research square (2023)
CD45RA + effector memory (EM) CD8 + T cell expansion was reported in Alzheimer's disease (AD). Such cells are IL-7 receptor alpha (IL-7Rα) low EM CD8 + T cells, which expand with age and have a unique aging gene signature (i.e., IL-7Rα low aging genes). Here we investigated whether IL-7Rα low aging genes and previously reported AD and memory (ADM) genes overlapped with clinical significance in AD patients. RT-qPCR analysis of 40 genes, including 29 ADM, 9 top IL-7Ra low aging and 2 control genes, showed 8 differentially expressed genes between AD and cognitively normal groups; five (62.5%) of which were top IL-7Rα low aging genes. Over-representation analysis revealed that these genes were highly present in molecular and biological pathways associated with AD. Distinct expression levels of these genes were associated with neuropsychological testing performance in 3 subgroups of dementia participants. Our findings support the possible implication of the IL-7Rα low aging gene signature with AD.
Keyphrases
- genome wide
- genome wide identification
- genome wide analysis
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