USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1.

Qingsong WuYuanyuan QiuJinhui GuoZibo YuanYingnan YangQingwei ZhuZhe ZhangJunwei GuoYanfang WuJunyu ZhangDongsheng HuangKangsheng TuXiaoge Hu

Published in: Biology direct (2024)

Our study reveals that USP40 enhances HCC malignant development by deubiquitinating and stabilizing Claudin1, suggesting that targeting USP40 may be a novel approach for HCC therapy.

Keyphrases

cell proliferation
stem cells
epithelial mesenchymal transition
cell cycle
drug delivery
signaling pathway
pi k akt