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Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates with Patent Ductus Arteriosus.

Kannan SridharanGeorge Priya Doss CHephzibah Cathryn RThirumal Kumar DMuna Al Jufairi
Published in: Current drug metabolism (2024)
We have identified CYP2D6*10 and CYP1A2*1C polymorphisms to significantly predict the therapeutic outcomes following the administration of paracetamol in preterm neonates with PDA. Prospective studies are required for confirmation of the findings in the vulnerable population.
Keyphrases
  • low birth weight
  • machine learning
  • preterm infants
  • preterm birth
  • artificial intelligence
  • big data
  • deep learning
  • anti inflammatory drugs
  • gestational age
  • high dose
  • case control