Login / Signup

A possible S-glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study.

Luisa ErcolaniAndrea ScirèRoberta GaleazziLuca MassaccesiLaura CianfrugliaAdolfo AmiciFrancesco PivaLorena UrbanelliCarla EmilianiGiovanni PrincipatoTiziana Bacchetti
Published in: Cell biochemistry and function (2017)
This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation using its natural substrate SLG, a glutathione derived compound. In this perspective, Glo2 can play a new important regulatory role inS-glutathionylation, acquiring further significance in cellular post-translational modifications of proteins.
Keyphrases
  • amino acid
  • molecular docking
  • protein protein
  • adverse drug
  • molecular dynamics simulations
  • structural basis