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Datumetine Preferentially Upregulates N-methyl-D-aspartate Receptor Signalling Pathways in Different Brain Regions of Mice.

Azeez Olakunle IsholaAdedeji Enitan AdetunjiIsaac Chukwunwike AbanumAdesola Akorede AdeyemiCaleb Kenechukwu FaleyeJane Babale MartinsNnenna Chimdalu OgbeToluwalase Cherish OgundipeKaren Ezichi OkewulonuUmo Emmanuel OkonDeborah Irenoise OvbudeRichard Yomi AkeleNaeemat Tolulope OmotadeMoyosore Salihu Ajao
Published in: Basic and clinical neuroscience (2023)
We conclude that a low dose of datumetine moderately enhances NMDAR activity. This showed the neuroprotective potentials of low datumetine exposure.
Keyphrases
  • low dose
  • cerebral ischemia
  • resting state
  • high fat diet induced
  • white matter
  • high dose
  • functional connectivity
  • blood brain barrier
  • metabolic syndrome
  • insulin resistance
  • binding protein