Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk.

Hongquan QinJiali ChenKatia Bouchekioua-BouzaghouYa-Ming MengJordi Bach GrieraXue JiangXiangzhan KongMinghui WangQiuping XuPing-Pui Wong

Published in: Journal of translational medicine (2023)

These findings suggest that targeting MAGEA-mediated paracrine regulation of chemoresistance by immunotherapy can be an improved pancreatic cancer treatment strategy.

Keyphrases

cancer therapy
single cell
circulating tumor
bone marrow
cell therapy
cell free
single molecule
stem cells
nucleic acid
cancer stem cells