Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.

Nuria Perretta-TejedorJosé M Muñoz-FélixAnnette DüwelYaremi Quiros-LuisJosé L Fernández-MartínAna I MoralesFrancisco J López-HernándezJosé M López-NovoaCarlos Martínez-Salgado

Published in: Acta physiologica (Oxford, England) (2019)

Cardiotrophin-1 participates in the endogenous response that opposes renal damage by counteracting the inflammatory, apoptotic and fibrotic processes. And exogenous cardiotrophin-1 is proposed as a candidate for the treatment and prevention of chronic renal fibrosis.

Keyphrases

chronic kidney disease
oxidative stress
cell death
end stage renal disease
systemic sclerosis
risk assessment
anti inflammatory
adipose tissue
drug induced
smoking cessation