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Associations Between Mean HbA1c, HbA1c Variability, and Both Mortality and Macrovascular Complications in Patients with Diabetes Mellitus: A Registry-Based Cohort Study.

Joshua Kuan TanGek Hsiang LimNur Nasyitah Mohamed SalimSing Yi ChiaJulian ThumbooYong Mong Bee
Published in: Clinical epidemiology (2023)
Both low (<6.0% [42 mmol/mol]) and high (≥8.0% [64 mmol/mol]) levels of glycaemic control are associated with increased all-cause mortality and diabetes-related macrovascular complications. Glycaemic variability is independently associated with increased risk for these outcomes. Therefore, patients with stable glycaemic level of 6-8% (42-64mmol/mol) are at lowest risk of all-cause mortality and diabetes-related macrovascular complications.
Keyphrases
  • type diabetes
  • glycemic control
  • risk factors
  • cardiovascular disease
  • insulin resistance
  • cardiovascular events
  • metabolic syndrome
  • adipose tissue
  • coronary artery disease