Hyperandrogenism and menstrual imbalance are the best predictors of metformin response in PCOS patients.

Emanuele GarziaValentina GalianoGiovanni MarfiaStefania NavoneEnzo GrossiAnna Maria Marconi

Published in: Reproductive biology and endocrinology : RB&E (2022)

In women with PCOS, menstrual pattern imbalance and ovarian androgens excess are the best predictors of metformin response. They may pave the way for a rethinking of the criteria for evaluating hyperandrogenism in order to better define the large population included in the diagnosis of PCOS. Baseline plasma testosterone level can serve as a sensitive marker to predict treatment compliance.

Keyphrases

polycystic ovary syndrome
insulin resistance
end stage renal disease
ejection fraction
peritoneal dialysis
prognostic factors
adipose tissue
patient reported outcomes
skeletal muscle
patient reported