OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.

Yizhou FengYuan YuanHongxia XiaZhaopeng WangYan CheZhefu HuJiangyang DengFangfang LiQingqing WuZhouyan BianHeng ZhouDifei ShenQi-Zhu Tang

Published in: Journal of translational medicine (2023)

OSMR deficiency aggravated pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling, which provided evidence that OSMR might be an attractive target for treating pathological cardiac hypertrophy and heart failure.

Keyphrases

heart failure
high glucose
diabetic rats
cell proliferation
signaling pathway
drug induced
replacement therapy
atrial fibrillation
cardiac resynchronization therapy