The role of transforming growth factor beta in bicuspid aortic valve aortopathy.
Nimrat GrewalOnur DolmaciArthur KlautzJuno LegueAntoine DriessenRobert KlautzRobert PoelmannPublished in: Indian journal of thoracic and cardiovascular surgery (2023)
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-β) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients.
Keyphrases
- aortic valve
- transforming growth factor
- aortic aneurysm
- aortic stenosis
- epithelial mesenchymal transition
- transcatheter aortic valve replacement
- aortic valve replacement
- transcatheter aortic valve implantation
- public health
- signaling pathway
- aortic dissection
- ejection fraction
- spinal cord
- newly diagnosed
- prognostic factors
- emergency department
- left ventricular
- heart failure
- pi k akt
- spinal cord injury
- coronary artery disease
- patient reported outcomes
- risk factors