APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.

Duowei WangXianjing LiJiani LiYuan LuSen ZhaoXinying TangXin ChenJiaying LiYan ZhengShuran LiRui SunMing YanDecai YuGuangwen CaoYong Yang

Published in: Gut (2019)

Our observations uncover a deaminase-independent role of the A3B in modulating the HCC microenvironment and demonstrate a proof for the concept of targeting A3B in HCC immunotherapy.

Keyphrases

stem cells
signaling pathway
cancer therapy