Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice.

C Alicia TraughberKara TiminskiAshutosh PrinceNilam BhandariKalash NeupaneMariam R KhanEsther OpokuEmmanuel OpokuGregory BrubakerJunchul ShinJunyoung HongBabunageswararao Kanuri Elif Gulin Ertugral-Samgar Prabhakara R Nagareddy Chandrasekhar R Kothapalli Olga A Cherepanova Jonathan D Smith Kailash Gulshan

Published in: Journal of the American Heart Association (2024)

Taken together, our data show that disulfiram can simultaneously modulate several atheroprotective pathways in a GsdmD-dependent as well as GsdmD-independent manner.

Keyphrases

cell death
electronic health record
endoplasmic reticulum stress
high fat diet induced
cardiovascular disease
signaling pathway
big data
oxidative stress
type diabetes
wild type
adipose tissue
data analysis