Semaglutide as a therapeutic option for elderly patients with type 2 diabetes: Pooled analysis of the SUSTAIN 1-5 trials.
Mark L WarrenLouis ChaykinDavid TrachtenbargGurudutt NayakNelun WijayasingheBertrand CariouPublished in: Diabetes, obesity & metabolism (2018)
The efficacy and safety of semaglutide vs comparators in non-elderly (<65 years) and elderly (≥65 years) patients with type 2 diabetes (T2D) across the SUSTAIN 1-5 trials were evaluated. Patients were randomized to once-weekly subcutaneous semaglutide (0.5 or 1.0 mg) vs placebo, sitagliptin, exenatide or insulin. The primary objective was change in HbA1c and secondary objectives were changes in body weight and safety. Mean HbA1c decreased from baseline by 1.2%-1.5% and 1.5%-1.9% vs 0%-0.9% (non-elderly, n = 3045) and by 1.3%-1.5% and 1.2%-1.8% vs 0.2%-1.0% (elderly, n = 854) with semaglutide 0.5 and 1.0 mg vs comparators. Similar reductions from baseline in mean body weight with semaglutide occurred in both age groups. Similar proportions of patients experienced adverse events; premature treatment discontinuations were higher in elderly vs non-elderly patients. No increased risk of severe or blood glucose-confirmed hypoglycaemia was seen with semaglutide vs comparators between age groups. Semaglutide had a comparable efficacy and safety profile in non-elderly and elderly patients across the SUSTAIN 1-5 trials, making it an effective treatment option for elderly patients with T2D.
Keyphrases
- middle aged
- body weight
- community dwelling
- end stage renal disease
- blood glucose
- type diabetes
- chronic kidney disease
- newly diagnosed
- ejection fraction
- prognostic factors
- blood pressure
- open label
- patient reported outcomes
- metabolic syndrome
- adipose tissue
- early onset
- phase iii
- glycemic control
- placebo controlled
- combination therapy
- replacement therapy
- drug induced