New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity.

Angelika KamizelaBarbara GawdzikMariusz UrbaniakŁukasz LechowiczAgata BiałońskaSylwia Ewa KutniewskaWeronika GonciarzMagdalena Chmiela

Published in: Molecules (Basel, Switzerland) (2019)

This paper presents the synthesis of γ -halo- δ -lactones, δ -iodo- γ -lactones and δ -hydroxy- γ -lactones from readily available organic substrates such as trans-crotonaldehyde and aryl bromides. Crystal structure analysis was carried out for lactones that were obtained in crystalline form. All halo- δ -lactones and δ -hydroxy- γ -lactones were highly cytotoxic against gastric cancer AGS cells with I C 50 values in the range of 0.0006-0.0044 mM. Some lactones showed high bactericidal activity against E. coli ATCC 8739 and S. aureus ATCC 65389, which reduced the number of CFU/mL by 70-83% and 87% respectively.

Keyphrases

crystal structure
escherichia coli
induced apoptosis
oxidative stress
cell death
cell proliferation
room temperature
cell cycle arrest