Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells.
Yajun WuPengyuan LiuWendy ChenShiting BaiSisi ChenJianglin ChenXiaogang XuJindan XiaYufei WuJianjun LaiChuan SunZhenghong LaoXiaoqing WanZhibing WuPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2024)
MW-HT + RT treatment significantly inhibited DNA damage repair by downregulating DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways, leading to increased ROS levels, aggravate DNA damage, apoptosis, and necrosis in PC3 cells, a well-established model of CRPC.
Keyphrases
- dna damage
- dna repair
- oxidative stress
- induced apoptosis
- cell cycle arrest
- dna damage response
- pi k akt
- endoplasmic reticulum stress
- signaling pathway
- diabetic rats
- cell death
- ischemia reperfusion injury
- squamous cell carcinoma
- single molecule
- cell free
- epithelial mesenchymal transition
- benign prostatic hyperplasia
- locally advanced
- radiofrequency ablation
- combination therapy