DNA methylation of skeletal muscle function-related secretary factors identifies FGF2 as a potential biomarker for sarcopenia.

Jia-Wen LiZheng-Kai ShenYu-Shuang LinZhi-Yue WangMei-Lin LiHui-Xian SunQuan WangCan ZhaoJin-Shui XuXiang LuWei Gao

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Our results suggest that lower FGF2_30 methylation is correlated with the risk and severity of sarcopenia in the older adults, indicating that FGF2 methylation serve as a surrogate biomarker for the screening and evaluation of sarcopenia.

Keyphrases

skeletal muscle
dna methylation
genome wide
insulin resistance
gene expression
physical activity
community dwelling
copy number
type diabetes
metabolic syndrome
drug induced