Significance of HER2 in Microinvasive Breast Carcinoma.

Huina ZhangIoana MoisiniBradley M TurnerXi WangAjay DhakalQi YangSierra KovarLinda M SchiffhauerDavid G Hicks

Published in: American journal of clinical pathology (2021)

Similar to the larger size of invasive breast carcinomas, HER2 positivity is associated with high-grade morphologic features in MiBCs. However, HER2 overexpression in MiBCs does not appear to be associated with nodal metastasis or worse outcome in our study cohort. The role of HER2-targeted therapy in this clinical setting merits additional study.

Keyphrases

high grade
cell proliferation
squamous cell carcinoma
low grade
radiation therapy