A mitochondria-targeting fluorescent probe for the selective detection of glutathione in living cells.

Xue-Liang LiuLi-Ya NiuYu-Zhe ChenMei-Ling ZhengYunxu YangQing-Zheng Yang

Published in: Organic & biomolecular chemistry (2018)

We report a fluorescent probe for the selective detection of mitochondrial glutathione (GSH). The probe, containing triphenylphosphine as a mitochondrial targeting group, exhibited ratiometric and selective detection of GSH over Cys/Hcy. The probe was used for imaging mitochondrial GSH in living HeLa cells.

Keyphrases

fluorescent probe
living cells
oxidative stress
loop mediated isothermal amplification
label free
real time pcr
induced apoptosis
cell cycle arrest
cancer therapy
high resolution
cell death
cell proliferation
nitric oxide
signaling pathway
reactive oxygen species
photodynamic therapy
single molecule