Ykt6 mediates autophagosome-vacuole fusion.

Levent BasDaniel PapinskiClaudine Kraft

Published in: Molecular & cellular oncology (2018)

Studying the mechanism of autophagosome-vacuole fusion has proven difficult in live yeast cells. Developing a novel in vitro fusion assay, we identified Ykt6 as the missing R-SNARE (Soluble N-ethylmaleimide sensitive factor attachment protein receptor) in this process and pinpoint the place of action of all four SNAREs involved. Parallel studies have confirmed our findings in other organisms.

Keyphrases

induced apoptosis
cell cycle arrest
high throughput
binding protein
cell death
saccharomyces cerevisiae
endoplasmic reticulum stress
protein protein