Estimating SARS-CoV-2 infections and associated changes in COVID-19 severity and fatality.
Valentina MarzianoGiorgio GuzzettaFrancesco MenegaleChiara SaccoDaniele PetroneAlberto Mateo UrdialesMartina Del MansoAntonino BellaMassimo FabianiMaria Fenicia VescioFlavia RiccardoPiero PolettiMattia ManicaAgnese ZardiniValeria d'AndreaFilippo TrentiniPaola StefanelliGiovanni RezzaAnna Teresa PalamaraSilvio BrusaferroMarco AjelliPatrizio PezzottiStefano MerlerPublished in: Influenza and other respiratory viruses (2023)
Since 2021, changes in the dominant SARS-CoV-2 variant, vaccination rollout, and the shift of infection to younger ages have reduced SARS-CoV-2 infection ascertainment. The same factors, combined with the improvement of patient management and care, contributed to a massive reduction in the severity and fatality of COVID-19.