Successful treatment of urticarial vasculitis with omalizumab in children: a case series.

Urticarial vasculitis (UV) is a small vessel leukocytoclastic vasculitis, which often needs to be distinguished from urticaria and other dermatoses. Treatment of UV in children is challenging because of the unsatisfying efficacy of antihistamines and the safety concern of long-term systemic corticosteroids or immunosuppressive agents. As a classical biological agent widely used in chronic spontaneous urticaria, omalizumab might also be a potential therapeutic option in the treatment of UV children. This report presented four children, aged 4-6yrs, with glucocorticoid-unresponsive UV successfully treated by omalizumab, which provides evidence of omalizumab treatment of UV with good efficacy and tolerance in the pediatric population.