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NF-kappa B activation correlates with disease phenotype in Crohn's disease.

Yoo Min HanJaemoon KohJi Won KimChanghyun LeeSeong-Joon KohByeongGwan KimKook Lae LeeJong Pil ImJoo Sung Kim
Published in: PloS one (2017)
Crohn's disease patients with high NF-κB activation showed specific clinical manifestations of higher frequency of ileocolonic involvement and lower frequency of perianal involvement relative to those with low NF-κB activation. High NF-κB activity was associated with higher histologic scores. However, the NF-κB activity did not affect the outcome and disease course after surgery.
Keyphrases
  • signaling pathway
  • nuclear factor
  • lps induced
  • pi k akt
  • oxidative stress
  • inflammatory response
  • toll like receptor
  • immune response
  • cell proliferation