NF-kappa B activation correlates with disease phenotype in Crohn's disease.
Yoo Min HanJaemoon KohJi Won KimChanghyun LeeSeong-Joon KohByeongGwan KimKook Lae LeeJong Pil ImJoo Sung KimPublished in: PloS one (2017)
Crohn's disease patients with high NF-κB activation showed specific clinical manifestations of higher frequency of ileocolonic involvement and lower frequency of perianal involvement relative to those with low NF-κB activation. High NF-κB activity was associated with higher histologic scores. However, the NF-κB activity did not affect the outcome and disease course after surgery.