High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze.

Nicklas BrustadJens H GreveHooman MirzakhaniCasper-Emil T PedersenAnders U EliasenJakob StokholmJessica Lasky-SuKlaus BønnelykkeAugusto A LitonjuaScott T WeissHans Bisgaard Bo Lund Chawes

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)

We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences.

Keyphrases

high dose
high fat diet
stem cell transplantation
low dose
insulin resistance
type diabetes