Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS.
Shayaq Ul Abeer RasoolSairish AshrafMudasar NabiShariq Rashid MasoodiKhalid Majid FaziliShajrul AminPublished in: International journal of endocrinology (2021)
The INSR C/T SNP (rs1799817) does not increase the risk of PCOS in Kashmiri women. This SNP is unlikely to play a significant role in the development and manifestation of clinical symptoms of polycystic ovary syndrome.
Keyphrases
- polycystic ovary syndrome
- genome wide
- tyrosine kinase
- insulin resistance
- epidermal growth factor receptor
- dna methylation
- high density
- type diabetes
- copy number
- genetic diversity
- oxidative stress
- adipose tissue
- metabolic syndrome
- gene expression
- physical activity
- depressive symptoms
- genome wide identification
- cervical cancer screening