Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.
Rowan SalonerLawren VandeVredeBreton M AskenEmily W PaolilloEva Q GontrumAmy WolfArgentina Lario-LagoMarta Milà-AlomàGallen Triana-BaltzerHartmuth C KolbDena B DubalGil D RabinoviciBruce L MillerAdam L BoxerKaitlin B CasalettoJoel H KramerPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Plasma p-tau217 may capture earlier Alzheimer's disease (AD)-related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology.