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Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.

Rowan SalonerLawren VandeVredeBreton M AskenEmily W PaolilloEva Q GontrumAmy WolfArgentina Lario-LagoMarta Milà-AlomàGallen Triana-BaltzerHartmuth C KolbDena B DubalGil D RabinoviciBruce L MillerAdam L BoxerKaitlin B CasalettoJoel H Kramer
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Plasma p-tau217 may capture earlier Alzheimer's disease (AD)-related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology.
Keyphrases
  • cognitive decline
  • mild cognitive impairment
  • resting state
  • white matter
  • cerebrospinal fluid
  • functional connectivity
  • cerebral ischemia
  • multiple sclerosis