Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.

Rowan SalonerLawren VandeVredeBreton M AskenEmily W PaolilloEva Q GontrumAmy WolfArgentina Lario-LagoMarta Milà-AlomàGallen Triana-BaltzerHartmuth C KolbDena B DubalGil D RabinoviciBruce L MillerAdam L BoxerKaitlin B CasalettoJoel H Kramer

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Plasma p-tau217 may capture earlier Alzheimer's disease (AD)-related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology.

Keyphrases

cognitive decline
mild cognitive impairment
resting state
white matter
cerebrospinal fluid
functional connectivity
cerebral ischemia
multiple sclerosis