Increased TBX6 gene dosages induce congenital cervical vertebral malformations in humans and mice.

Xiaojun RenNan YangNan WuXiming XuWeisheng ChenLing ZhangYingping LiRen-Qian DuShuangshuang DongSen ZhaoShuxia ChenLi-Ping JiangLianlei WangJianguo ZhangZhihong WuLi JinGuixing QiuJames R LupskiJiangang ShiFeng ZhangPengfei Liu

Published in: Journal of medical genetics (2019)

Our findings in humans and mice consistently support that an increased TBX6 dosage contributes to the risk of developing cervical CVMs.

Keyphrases

high fat diet induced
genome wide
copy number
bone mineral density
gene expression
insulin resistance
type diabetes
metabolic syndrome
adipose tissue
body composition
skeletal muscle