Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions.

Kanishk JainCaroline S FraserMatthew R MarundeMadison M ParkerCari SagumJonathan M BurgNathan HallIrina K PopovaKeli L RodriguezAnup VaidyaKrzysztof KrajewskiMichael-Christopher KeoghMark T BedfordBrian D Strahl

Published in: Epigenetics & chromatin (2020)

The high-throughput approaches utilized in this study establish a compendium of binding information for the PHD reader family with regard to how they engage histone PTMs and uncover several novel reader domain-histone PTM interactions (i.e., PHRF1 and TRIM66). This study highlights the usefulness of high-throughput analyses of histone reader proteins as a means of understanding how chromatin engagement occurs biochemically.

Keyphrases

high throughput
dna methylation
gene expression
dna damage
single cell
healthcare
oxidative stress
binding protein