Priming with inflammatory cytokines is not a prerequisite to increase immune-suppressive effects and responsiveness of equine amniotic mesenchymal stromal cells.

Anna Lange-ConsiglioPietro RomeleMarta MagattiAntonietta SiliniAntonella IddaNicola Antonio MartinoFausto CremonesiOrnella Parolini

Published in: Stem cell research & therapy (2020)

AMSCs and their CM have a strong capacity to inhibit PBMC proliferation, and priming is not necessary to improve their immunosuppressive activity or reactivity in an inflammatory in vitro model.

Keyphrases

bone marrow
signaling pathway
oxidative stress
umbilical cord
mesenchymal stem cells