Covalent Organic Frameworks (COFs) for Cancer Therapeutics.
Qun GuanLe-Le ZhouWen-Yan LiYan-An LiYu-Bin DongPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
As newly emerged crystalline porous materials, covalent organic frameworks (COFs) possess fascinating structures and some specific features such as modularity, crystallinity, porosity, stability, versatility, and biocompatibility. Besides adsorption/separation, sensing, catalysis, and energy applications, COFs have recently shown a promise in biomedical applications. This contribution provides an overview of the recent developments of COF-based medicines in cancer therapeutics, including drug delivery, photodynamic therapy (PDT), photothermal therapy (PTT), and combined therapy. Furthermore, the major challenges and developing trends in this field are also discussed. These recent developments are summarized and discussed to help encourage further contributions in this emerging and promising field.
Keyphrases
- photodynamic therapy
- papillary thyroid
- drug delivery
- squamous cell
- small molecule
- fluorescence imaging
- high resolution
- mesenchymal stem cells
- squamous cell carcinoma
- machine learning
- big data
- mass spectrometry
- artificial intelligence
- smoking cessation
- highly efficient
- metal organic framework
- replacement therapy
- drug release
- ionic liquid