Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.
Laura M TaylorPamela J McMillanNicole F LiachkoTimothy J StrovasBernardino GhettiThomas D BirdC Dirk KeeneBrian C KraemerPublished in: Molecular neurodegeneration (2018)
Our findings suggest a possible etiology for the two most common FTLD subtypes through a kinase activation driven mechanism of neurodegeneration.