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Dynamics and bifurcations in multistable 3-cell neural networks.

J CollensKrishna PusuluriA KelleyD KnapperT XingS BasodiD AlacamAndrey L Shilnikov
Published in: Chaos (Woodbury, N.Y.) (2021)
We disclose the generality of the intrinsic mechanisms underlying multistability in reciprocally inhibitory 3-cell circuits composed of simplified, low-dimensional models of oscillatory neurons, as opposed to those of a detailed Hodgkin-Huxley type [Wojcik et al., PLoS One 9, e92918 (2014)]. The computational reduction to return maps for the phase-lags between neurons reveals a rich multiplicity of rhythmic patterns in such circuits. We perform a detailed bifurcation analysis to show how such rhythms can emerge, disappear, and gain or lose stability, as the parameters of the individual cells and the synapses are varied.
Keyphrases
  • neural network
  • single cell
  • cell therapy
  • spinal cord
  • induced apoptosis
  • cell cycle arrest
  • high frequency
  • mesenchymal stem cells
  • bone marrow