Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways.

Jianxiang XuLifeng FuJinwu BaiHuiming ZhongZhihui KuangChengwei ZhouBin HuLicheng NiLi YingErman ChenWei ZhangJiaqi WuDeting XueWeixu LiZhi-Jun Pan

Published in: Stem cell research & therapy (2021)

Collectively, our study demonstrate that low-dose IL-34 regulates osteogenesis of hBMSCs partly via the PIK/AKT and ERK signaling pathway and enhances fracture healing, with neither promoting nor preventing osteoclastogenesis in vitro and osteoporosis in vivo.

Keyphrases

signaling pathway
low dose
pi k akt
induced apoptosis
epithelial mesenchymal transition
high dose
cell proliferation
postmenopausal women
lps induced
bone loss
oxidative stress
hip fracture