Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination.

Ziena AbdulrahmanNoel F C C de MirandaEdith M G van EschPeggy J de Vos van SteenwijkHans W NijmanMarij J P WeltersMariette I E van PoelgeestSjoerd H Van der Burg

Published in: Journal for immunotherapy of cancer (2021)

A prevaccination inflamed type 1 immune contexture is required for stronger vaccine-induced immune infiltration and is associated with better clinical response. Therapeutic vaccination did not overtly increase immune infiltration of cold lesions.

Keyphrases

high grade
low grade
stem cells
oxidative stress
high glucose
endothelial cells
diabetic rats
neoadjuvant chemotherapy